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  [摘要] 目的:探讨P16和Ki-67在外阴上皮内瘤变(VIN)组织中的表达及其意义。方法：采用免疫组化SP法检测44例VIN(VINⅠ16例，VINⅡ、Ⅲ 28例)组织中P16和Ki-67的原位表达，并以30例正常外阴组织作为对照。结果：对照组、低级别VIN(VINⅠ)和高级别VIN(VINⅡ、Ⅲ)组织中P16的阳性率依次为7%、44%和100%，Ki-67的阳性率依次为10%、75%和100%；P16和Ki-67在VINⅡ、Ⅲ和对照组，VINⅡ、Ⅲ和VINⅠ之间的阳性表达率差异均具有统计学意义(P1， LI Dai-qiang2

 (1. Department of Pathology, the People's Hospital of Xiangxiang, Xiangxiang 411400, China； 2. Department of

 Pathology, Xiangya Second Hospital of Zhongnan University, Changsha 410011, China)

 [Abstract] Objective: To investigate the effects of P16 and Ki-67 on vulvar intraepithelial neoplasia(VIN). Methods: The expression of P16 and Ki-67 in situ in the lesion of 44 patients[16 low-grade VIN(VIN Ⅰ), and 28 high-grade VIN(VINⅡand Ⅲ)] were examined by immunohistochemical assay；and 30 normal vulvar tissues were treated as controls. Results: The positive percentages of P16 in normal vulvar tissues, VIN Ⅰ,Ⅱ, Ⅲ were 7%,44%,100% respectively; The positive percentages of Ki-67 in normal vulvar tissues, VIN Ⅰ,Ⅱ, Ⅲ were 10%，75%，100% respectively. The expressions of P16 and Ki-67 had significant differences between the high grade and low grade VIN(P
 http://www.100md.com/html/paper/1671-7562/2011/01/08.htm
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