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  [摘要] 目的 探讨原发性高血压患者血压变异性(blood pressure variability，BPV)和炎症标志物TNF-α、IL-6、hs-CRP之间的联系。 方法 62例原发性高血压患者均进行24 h动态心血压监测和清晨空腹采血，采用双抗体夹心ABC-ELISA法检测血清IL-6和TNF-α水平；免疫透射比浊法检测血清高敏C反应蛋白(hs-CRP)水平。BPV通过计算标准差(standard deviation，s)和血压变异系数(coefficient of variation，CV)获得。 结果 血压(BP)和TNF-α表达水平明显相关；IL-6表达水平和日间收缩压的s和CV相关，但和BP没有相关性；hs-CRP与BP及血压的s和CV均无明显相关性。相关性分析显示，日间收缩压的s(β = 0.066， P = 0.002)和年龄(β = 0.025， P = 0.018)均与IL-6呈明显正相关；日间舒张压(β = 0.031，P = 0.002)独立相关于TNF-α。 结论 原发性高血压人群中BPV与炎症标志物存在相关关系，提示高血压和靶器官损伤之间的联系可能与炎症的发生发展相关。

 [关键词] 原发性高血压；血压变异性；炎症

 [中图分类号] R544.1 [文献标识码] A [文章编号] 1673-7210(2012)02(b)-0039-03

 Research on the association between blood pressure variability and TNF-α, IL-6, hs-CRP in essential hypertension patients

 WANG Jiaci LIU Bayi LI Jiangong

 Department of Intensive Care Unit, Chinese Medical Hospital of Zhongshan City, Guangdong Province, Zhongshan 528400, China

 [Abstract] Objective To investigate the association between blood pressure variability(BPV) and inflammatory marker in hypertensive patients. Methods 62 cases of essential hypertension patients were performed 24 h ambulatory BP monitoring. Inflammatory markers were evaluated by measuring plasma levels of interleukin (IL)-6, tumornecrosis factor (TNF)-α by a dual antibody sandwich enzyme-linked immunosorbent assay (ELISA); levels of high sensitive C-reactive protein (hs-CRP) were mesaured by immunoturbidimetry. BPV was obtained by calculating within-subject standard deviation (s) and coefficient of variation of BP. Results A significant association between ambulatory BP and TNF-α level was identified, while the BPV index was linked to IL-6 level, but no association was observed between BP and IL-6 level. However, no significant correlation was found between the hs-CRP concentration and the BP standard deviation or BP variability. Multiple linear regression models revealed that the s of daytime systolic BP (β = 0 ......