【摘要】 目的：分析合并食管外症状的胃食管反流病(GERD)患者的食管动力。方法：选取就诊福建省立医院的GERD患者93例，将50例有食管外症状患者设为食管外症状组，将43例无食管外症状患者设为无食管外症状组;另选取33例健康志愿者设为对照组。比较分析三组高分辨率食管测压数据。结果：食管外症状组LES长度、LESP、无效吞咽率与无食管外症状组比较差异无统计学意义(P>0.05)，但两组LES长度均短于对照组，LESP低于对照组，无效吞咽率高于对照组，差异均有统计学意义(P0.05)，但两组UES长度均显著短于无食管外症状组，差异有统计学意义(P0.05)。结论：合并食管外症状的GERD患者的UES长度无代偿性延长，提示其UES的收缩功能减退。

 【关键词】 胃食管反流病 食管外症状 高分辨率食管测压 食管动力

 doi：10.14033/j.cnki.cfmr.2020.25.050 文献标识码 B 文章编号 1674-6805(2020)25-0-03

 [Abstract] Objective： To analyze the esophageal motility of gastroesophageal reflux disease (GERD) patients with extra-esophageal symptoms. Method： A total of 93 GERD patients admitted in Fujian Provincial Hospital were selected. Fifty patients with extra-esophageal symptoms were set as the extra-esophageal symptoms group， and 43 patients without extra-esophageal symptoms were set as the without extra-esophageal symptoms group. and 33 healthy volunteers were selected as the control group. The high-resolution esophageal manometry data of the three groups were compared and analyzed. Result： There were no statistically significant differences in LES length， LESP， and invalid swallowing rate between the extra-esophageal symptoms group and the without extra-esophageal symptoms group (P>0.05). However， LES length in both groups was shorter than that in the control group， LESP was lower than that in the control group， and invalid swallowing rate was higher than that in the control group， and the differences were statistically significant (P0.05)， but the UES length in both groups was significantly shorter than that in the without extra-esophageal symptoms group， the differences were statistically significant (P0.05). Conclusion： There is no compensatory lengthening of UES length in GERD patients with extra-esophageal symptoms， suggesting decreased UES systolic function.

 [Key words] Gastroesophageal reflux disease Extra-esophageal symptoms High-resolution esophageal manometry Esophageal motility

 First-author’s address： Geriatric Hospital of Fujian Province， Fuzhou 350001， China

 胃食管反流病(gastroesophageal reflux disease，GERD)的臨床症状多种多样，常表现为咳嗽、咽部异物感、喘息、声嘶等食管外症状[1]。随着24 h pH-阻抗动态监测的发展，越来越多的合并食管外症状的GERD得到正确诊断，但其有效治疗率仍不乐观。食管动力障碍是GERD的病理生理学基础，认识合并食管外症状的GERD的食管动力特点，能够对其的诊治提供理论依据。本文通过对比分析合并食管外症状的GERD患者、无食管外症状的GERD患者及健康志愿者的高分辨率食管测压数据，揭示合并食管外症状的GERD患者的食管动力特点，现报道如下。, http://www.100md.com(沈玉玲 曾庆新 林志辉) 第 1 2 3 页 下一页
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