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  [摘要] 目的 研究呼吸睡眠紊乱对慢性阻塞性肺疾病急性加重期(AECOPD)患者动脉血气的影响。方法 选取86例单纯AECOPD(AECOPD组)和27例重叠综合征(OS)患者(OS组),分别在入院及出院时抽动脉血,比较动脉血气的变化特点。结果 OS组治疗前后动脉血pH、动脉血氧分压(PaO2)和动脉血氧饱和度(SaO2)均低于AECOPD组(P2饱和度(PaCO2)均高于AECOPD组(P2、PaO2和SaO2均基本恢复正常,而OS组PaCO2及PaO2仍未能恢复正常,两组间比较差异有统计学意义(P2, SaO2of all OS patients were lower than those of AECOPD patients, and PaCO2 was higher than those of AECOPD patients. Even though pH, PaCO2, PaO2, SaO2 of AECOPD patients were restored to their original conditions after treatment, hypercapnia and relatively low oxygen saturation continued to exist in OS patients.The difference between the two groups is statistically significant.Conclusion Sleep apnea hypopnea is one of the most important factors for exacerbating hypoxemia,carbon dioxide retention and acidosis.

 Key words:chronic obstructive pulmonary disease;acute exacerbation;overlap syndrome;blood gas analysis 

 (Modern Medical Journal,2009,37:258-260)

 慢性阻塞性肺疾病(COPD)是一种以气流受限并且不能完全可逆为特征的可以预防和治疗的疾病,是累及气道、肺实质以及肺血管的慢性炎症 ......