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Abstract：[Objective]To study the biological of β-carotene on oxidative damage induced by cigarette smoke。[Methods]Deoxyribose(DR)degradation and plasmid DNA methods were used to detemine oxidative damage of aqueous cigarette smoke solution(ACSS)and effects ofβ-carotene。ROSinduced strongly DR degradation and DNA damage。β-carotene showed slight protecion of DR degradation of ACSS at a hige coonentration，and potent protectiveeffects on DNA damage of ACSS at a lower concentration。[Conclusion]Large amount of long half life reactive oxygen species was generated from aqueous solution of cigarette smoke。β-carotene exerted antioxidat8ive effect on oxidative damage induced by ACSS。
Key Words：oxidative damage；cigarette smoke；β-carotene
http://www.100md.com/html/paper/1006-3617/2004/01/09.htm
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