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  [摘要]目的:回顾204例定期随访的门诊雄激素源性脱发(androgenic alopecia,AGA)患者的病例资料,分析影响疗效的相关因素。方法:采用SAS 8.0分析疗效与疾病严重程度、病程、发病年龄、治疗时间、治疗方式等的相关性。结果:患者多为病程在5年内、严重程度为中度的男性;患者评价和医生评价结果显示,疗效与用药时间相关系数分别为0.36和0.40,与严重程度相关系数为0.276和0.287,均P0.01。说明疾病严重程度越重的、治疗时间越长的,疗效越明显。从治疗方式上看,联合治疗有效率最高,单纯口服次之,单纯外用最低。结论:疗效与病情严重程度和治疗时间呈正相关,而与病程、发病年龄等无明显相关性。联合治疗较单独口服或者外用治疗效果更好。

 [关键词]雄激素源性脱发;疗效;相关因素

 [中图分类号]R758.71[文献标识码]A [文章编号]1008-6455(2010)08-1176-04

 Analysis of influencing factors to the therapeutic effect of androgenetic alopecia

 ZHANG Jin-yan,ZHONG Shao-min,YANG Shu-xia,WU Yan

 (Department of Dermatological,Peking University First Hospital,Beijing100034,China)

 Abstract:ObjectiveReview 204 regularly follow-up cases of androgenetic alopecia and analyze the influencing factors to therapeutic effect. Methods Using analysis software SAS 8.0 to analyze the association between therapeutic effect and severity,course,morbidity age,treatment time and treatment method.ResultsMost of patients were males, with course less than 5 years.Most of them had moderate AGA.Patients'and doctor's evaluation revealed correlation coefficient of therapeutic effect with treatment time were 0.36 and 0.40,P0.01.It implied that the more serious the AGA was,the longer the therapy lasted,then the better the effect was. As for treatment methods, the efficiency of combined therapy was the highest,the oral treatment had better result compared with topical treatment alone.Conclusion Therapeutic effect hadpositive correlation with severity and treatment time. Therapeutic effect had no correlation with course and morbidity age.The efficiency of combined therapy was better than that of mono-therapy.

 Key words:androgenetic alopecia ;therapeutic effect;influencing factors

 雄激素源性脱发(androgenic alopecia,AGA)又称为男性型脱发、脂溢性脱发,是临床上最常见的脱发类型,表现为前额发际逐渐后退,或顶部头发逐渐稀疏、脱落,多发于20～30岁的男性,部分患者有家族史。目前对AGA最常用的治疗方法有口服非那雄胺、外用米诺地尔溶液、口服和外用相结合的联合治疗、毛发移植等 ......